CareLit Fachartikel
Programmed cell death protein 4 suppresses CDK–1/cdc 2 via induction of p21Waf1/Cip1
R Göke · Zeitschrift für Gastroenterologie · 2004 · Heft 08
Dokument
1101255
CareLit-ID
Jahr
2004
Publikation
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Metadaten
DOI
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Zusammenfassung
Programmed cell death, also termed apoptosis, plays a fundamental role in many biological processes as embryogenesis, normal tissue turnover and immune homeostasis. Although to date a number of caspase-dependent and –independent apoptotic pathways have been identified the mechanisms of cell death are very complex and are still largely unknown. In an attempt to identify genes which are involved in the regulation of apoptosis we cloned rat pdcd4 (=DUG; death upregulated gene). Pdcd4 is constitutively expressed at low levels in normal cells but is upregulated after induction of apoptosis by different stimuli like d…
Schlagworte
cell cycle
colon cancer
pdcd4
tumor suppressor gene
Apoptosis
Tumor
Breast
After
Zeitschrift für Gastroenterologie
