CareLit Fachartikel
Atorvastatin induces Apoptosis in Rat Liver Hepatic Stellate Cells (HSC) by a Caspase–9 dependant Pathway
I Aprigliano, J Dudas, G Ramadori, B Saile · Zeitschrift für Gastroenterologie · 2004 · Heft 08
Dokument
1101266
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Jahr
2004
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Zusammenfassung
Background and Aims: HMG-CoA reductase inhibitors (statins) are widely used in the clinic for their cholesterol-lowering properties and several studies suggest that statins are also capable to induce apoptosis in extracellular matrix (ECM)-producing cells. Activated hepatic stellate cells (HSCs) aquire the capacity to synthesize and degrade matrix proteins in the damaged liver. Therefore research on anti-fibrotic strategies has focussed on the investigation of apoptotic mechanisms in HSCs, and in testing the efficacy of various agents in inducing apoptosis in HSCs.? We tested the hypothesis that atorvastatin, on…
Schlagworte
atorvastatin
hepatic stellate cell
apoptosis
Caspase 9
Cholesterol
After
Zeitschrift für Gastroenterologie
