Spreading Depression and Epileptic Activity in Living Human Neocortical Tissues

The close kinship between spreading depression (SD) and experimental epileptic activity has stimulated extensive investigation into the mutual relationship of these two phenomena. Despite the many studies into the simultaneous occurrence of SD and epileptiform burst discharges in animal neuronal tissues, the interaction of these phenomena in human neuronal tissues is not clear. Therefore, the effect of SD on the bioelectrical activity of human neocortical tissues was tested in neocortical slice preparations from 15 patients who underwent surgery for the treatment of refractory epilepsy. Synchronous rhythmic shar…