Neurobiological Correlates of Disturbed Cognitive Functions in Patients with Schizophrenia: A Simultaneous EEG + fMRI Study

Currently, there is evidence demonstrating that schizophrenia is an illness characterized by multiple deficits in fundamental cognitive processes such as attention and memory. The P300 component of the event-related potential is thought to reflect various cognitive processes including the allocation of attentional resources to incoming stimuli. Reduction of the auditory P300 amplitude is constantly found in schizophrenic patients. Besides it could be shown that the P300 amplitude correlated negatively with the severity of thought disorders. Thus, the P300 appears to be a suitable functional parameter of thought…