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The Extent of Cytokine Induction in Peripheral Nerve Lesions Depends on the Mode of Injury and NMDA Receptor Signaling

C Kleinschnitz, J Brinkhoff, M Zelenka, C Sommer, G Stoll · Klinische Neurophysiologie · 2004 · Heft 08

Dokument
1101290
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Jahr
2004
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Neurophysiologie
Autor:innen
C Kleinschnitz, J Brinkhoff, M Zelenka, C Sommer, G Stoll
Ausgabe
Heft 08 / 2004
Seiten
–
Erschienen: 2004-08-25 00:00:00
ISSN
1434-0275
DOI
10.1055/s-2004-832047

Zusammenfassung

Background: Nerve injury leads to a degeneration of distal nerve segments, a process named Wallerian degeneration (WD). In the peripheral nervous system (PNS), WD is followed by prompt nerve regeneration facilitated by axonal sprouting from the proximal stumps of injured nerve fibers. Infiltration by inflammatory cells and local induction of chemokines and cytokines play an essential role in this process. Objectives: In the present study we asked whether cytokine gene induction is dependent on the mode of nerve injury and if it involves NMDA signaling. Methods: Interleukin (IL)-1beta, tumor necrosis factor (TNF)…

Schlagworte

Cytokine After Cytokines Chemokines Tumor Klinische Neurophysiologie