Decreased paired-pulse inhibition following induced cortical gliomas in the rat

Epilepsy is a poorly understood phenomenon of many patients with gliomas, meningiomas, and other brain tumor entities. Epileptic seizures are frequently the first symptoms of gliomas. The responsible functional modifications of neuronal activity by neoplastic cells are unknown. However, an imbalance of excitation and inhibition has been observed in the vicinity of the neoplasia. We have established a model that enables different experiments on identical tissue preparations. Inoculation of EGFP-transfected rat C6 glioma cells led to intracortical growing gliomas histologically resembling human gliobastomas. Gliom…