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Spreading Depression (SD) Waves in the Brainstem of Immature Rats Propagate Independently of Glutamatergic Synaptic Transmission
F Richter, A Lehmenkuhler, HG Schaible · Klinische Neurophysiologie · 2004 · Heft 08
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1101299
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Jahr
2004
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Zusammenfassung
Spreading depression (SD) is thought to occur mainly in the cerebral cortex but barely or not at all in other parts of the CNS. Specifically it was believed that the brainstem is not able to generate SDs. Recently, we confirmed that the brainstem of the adult rat does not show SDs but, interestingly, SDs could be elicited in the brainstem of rats younger than 13 days, when excitability was enhanced by replacing extracellular chloride ions with sodium acetate or by transient periods of asphyxia or hypoxia (2min breathing 6% O2 in N2). Sustained spreading depressions in the brainstem stopped breathing (Richter et…
Schlagworte
Depression
Calcium Channels
Asphyxia
Chloride
Acetate
Calcium
After
AMPA
Klinische Neurophysiologie
