Involvement of Primary Motor Cortex in Wilson's Disease Postural Tremor
M Suedmeyer, B Pollok, H Hefter, J Gross, L Wojtecki, M Butz, L Timmermann, A Schnitzler · Klinische Neurophysiologie · 2004 · Heft 08
Bibliografische Angaben
Zusammenfassung
Objective: The following study included five Wilson's disease (WD) patients showing a right-sided postural forearm tremor (4 6Hz) and addressed the question whether the primary motor cortex (M1) is directly involved in the generation of tremor. Methods: Using a 122-channel whole-head neuromagnetometer and surface EMGs we investigated cerebro-muscular coupling. Postural tremor was observed in a sustained 45° posture of the right-sided forearm. Data were analyzed using Dynamic Imaging of Coherent Sources (DICS), revealing cerebro-muscular coupling between EMG and cerebral activity. Coherent sources were superimpos…
