Stereotactic Radiosurgery for Hypothalamic Hamartoma

Hypothalamic hamartoma are non-neoplastic lesions often characterized by central precocious puberty and gelastic epilepsy. Due to their delicate location, surgery is often unsuccessful and associated with considerable risks. In the presented series, Gamma knife radiosurgery was applied. Four cases (aged between 5 and 13 years) who presented with medically intractable gelastic epilepsy and increasing secondary generalization, abnormal behaviour and precocious puberty (3 cases) are reported. Hypothalamic hamartomas 11–17mm in size had been diagnosed by MR imaging. Radiosurgical treatment was performed in general a…