CareLit Fachartikel
Compounds that inhibit amyloid formation of Huntington's and Alzheimer's disease proteins imply a common aggregation pathway
M Herbst, S Engemann, J Walther, R Lurz, V Heiser, EE Wanker · Aktuelle Neurologie · 2004 · Heft 09
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1101344
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Jahr
2004
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Zusammenfassung
Amyloid formation is widely accepted to play a crucial role in the pathogenesis of many neurodegenerative disorders including Alzheimer's disease (AD) and polyglutamine disorders such as Huntington's disease. The disease-specific amyloid-forming proteins share no sequence homologies and have different functions. However, recent studies demonstrated strong similarities in the process of protein aggregation despite the lack of identical sequences. For example, oligomeric intermediates made up of amyloid-beta, alpha-synuclein, polyglutamine protein, or other disease-associated amyloidogenic proteins are recognized…
Schlagworte
Amyloid
Amyloidogenic Proteins
Amyloid beta-Peptides
Drug Development
alpha-Synuclein
Aktuelle Neurologie
