Different Effects of the Functional MCP–1 Polymorphism (A–2518G) on Hepatic Fibrosis and Hepatocancerogenesis
M Mühlbauer, M Froh, F Stickel, A Hartmann, TS Weiss, J Schölmerich, C Hellerbrand · Zeitschrift für Gastroenterologie · 2005 · Heft 01
Bibliografische Angaben
Zusammenfassung
Monocyte chemotactic protein–1 (MCP–1) is a potent chemokine and its hepatic expression is upregulated during chronic liver disease mainly in activated hepatic stellate cells (HSC). Recently, the association of a functional genetic polymorphism of the MCP–1 promotor (A–2581G) with the severity of hepatic inflammation and fibrosis in patients with chronic hepatitis C (HCV) (Gastroenterology 2003;125(4): 1085–93) was demonstrated. The aim of this study was to investigate this polymorphism in patients with alcohol-associated cirrhosis (Alc-Ci) and in patients with hepatocellular carcinoma (HCC), since it is known t…
