Regulatory T Cells Suppress Virus-Specific CD8+ T Cell Proliferation During Chronic Hepatitis C Virus Infection
T Böttler, HC Spangenberg, C Neumann-Haefelin, E Panther, F von Weizsäcker, HE Blum, R Thimme · Zeitschrift für Gastroenterologie · 2005 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introd.: Chronic HCV infection is associated with impaired proliferative, cytokine and cytotoxic effector functions of HCV-specific CD8+ T cells, probably contributing significantly to viral persistence. Recently, Sugimoto et al. demonstrated that CD4+CD25+ regulatory T cells suppress ex vivo cytokine production of HCV-specific CD8+ T cells. Here, we investigated the potential role of CD4+CD25+ regulatory T cells (Treg cells) in suppressing virus-specific CD8+ T cell proliferation during chronic HCV infection. Meth.: PBMCs were obtained from 10 chronically HCV-infected patients, 10 patients after spontaneous or…
