Reperfusion Cellular Injury in Ischemic Stroke: Monitoring with Diffusion and Perfusion MRI
SK Lee · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2005 · Heft 04
Bibliografische Angaben
Zusammenfassung
Ziele: The purpose of this study was to investigate the serial changes in cerebral perfusion following transient ischemia by means of perfusion and diffusion weighted MRI. We also investigated the neuroprotective effect of agmatine in the case of reperfusion hyperemia by TUNEL assay. Methode: The one hour transient MCA occlusion model was produced in 25 cats (10 controls and 15 agmatine treated cats). Serial perfusion MRI (PWI) was performed for 3 days after reperfusion. The reperfusion characteristics in each region of the brain were classified into 4 groups according to the serial perfusion MRI status, with th…