Molecular imaging of gene therapy. The future in Parkinson's disease therapy?

Molecular imaging is a rapidly evolving field based on concerted research and new technical developments spanning on multiple disciplines. Especially for the development of successful implementation of new therapeutic modalities in PD, such as gene therapy, imaging of endogenous effector gene expression and imaging of cells as well as vector-mediated gene expression in vivo will be of critical importance. In a primate PD model, the therapeutic effect of lentiviral vector-mediated transduction of glial cell line-derived neurotrophic factor (GDNF) has been shown by measuring the improvement in endogenous enzymatic…