CareLit Fachartikel
Development of an EAE model for histopathological subtype II of MS: role of humeral immune system
T Ziemssen, H Schneider, J Bauer, A Iglesias · Aktuelle Neurologie · 2005 · Heft 10
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1102466
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Jahr
2005
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Zusammenfassung
Introduction: The considerable heterogeneity in the pathogenesis of MS is evidenced by identification of 4 distinct subtypes of MS. In subtype II lesions, humeral immune components (typical deposition of immunoglobulins and complement) are involved in addition to T cell and macrophage infiltration. Patients with subtype II lesions seem to respond to specific treatment regimes like plasma exchange. In addition, Berger et al. (2003) have shown that anti-myelin antibodies (Ab) (especially those directed to myelin oligodendrocytic glycoprotein (MOG)) could serve as marker in MS. Design/Methods: To investigate the ro…
Schlagworte
Antibodies
Antigen Presentation
Blood-Brain Barrier
Blood
Lead
Aktuelle Neurologie
