CareLit Fachartikel

Antiamphiphysin positive Stiff-person syndrome associated with small cell lung cancer

B.K Nguyen-Huu, P Urban, M Schreckenberger, T Hundsberger, M Dieterich, K.J Werhahn · Aktuelle Neurologie · 2005 · Heft 10

Dokument
1102481
CareLit-ID
Jahr
2005
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
B.K Nguyen-Huu, P Urban, M Schreckenberger, T Hundsberger, M Dieterich, K.J Werhahn
Ausgabe
Heft 10 / 2005
Seiten
–
Erschienen: 2005-10-26 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2005-919407

Zusammenfassung

Stiff-person syndrome (SPS) is a rare neurologic disorder characterized by progressive muscle rigidity mostly of autoimmunological aetiology, typically associated with autoantibodies to glutamic acid decarboxylase (GADs). However, approximately 5–10% of cases are of paraneoplastic aetiology usually having breast adenocarcinoma and are positive for autoantibodies against amphiphysin. Here, we describe the first case of a patient whose antiamphiphysin(+) SPS due to a small cell cancer of the lung. A 56-year old women presented with a six month history of increasing muscle cramps, stiffness of the right lower limb,…

Schlagworte

Breast Antibodies Autoantibodies Benzodiazepines Adenocarcinoma Cisplatin Biopsy Tumor Aktuelle Neurologie