CareLit Fachartikel

Protein patterns in cerebrospinal fluid of patients with amyotrophic lateral sclerosis: an analysis using proteomics

K Kollewe, N von Neuhoff, U Wurster, J Bufler, B Schlegelberger, R Dengler · Aktuelle Neurologie · 2005 · Heft 10

Dokument
1102504
CareLit-ID
Jahr
2005
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
K Kollewe, N von Neuhoff, U Wurster, J Bufler, B Schlegelberger, R Dengler
Ausgabe
Heft 10 / 2005
Seiten
–
Erschienen: 2005-10-26 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2005-919637

Zusammenfassung

The use of modern mass spectroscopy methods has made proteomics a promising new tool for the clinical diagnosis of Amyotrophic Lateral Sclerosis (ALS). Advanced pattern recognition algorithms are used to associate these fingerprints with known disease states, resulting in the identification of unique protein patterns that can distinguish between healthy and affected individuals. In this study, we used a chip- or a beads based method in combination with a SELDI-MS (surface enhanced laser desorption and ionization) to find differences in the cerebrospinal fluid (CSF)- proteome of patients with ALS and patients wit…

Schlagworte

Amyotrophic Lateral Sclerosis Algorithms After Diagnosis Lead Aktuelle Neurologie