CareLit Fachartikel

TGF-ß2 and it's role in the invasion of high-grade glioma into parenchyma

F Arslan, T Nickl-Jockschat, A Dörfelt, A Lohmeier, A Bosserhoff, U Bogdahn, P Hau · Aktuelle Neurologie · 2005 · Heft 10

Dokument
1102505
CareLit-ID
Jahr
2005
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
F Arslan, T Nickl-Jockschat, A Dörfelt, A Lohmeier, A Bosserhoff, U Bogdahn, P Hau
Ausgabe
Heft 10 / 2005
Seiten
–
Erschienen: 2005-10-26 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2005-919647

Zusammenfassung

Introduction: Invasion of high-grade gliomas into parenchyma is one of the hallmarks of these tumors preventing curative resections. TGF-ß2 plays a role in invasion and is able to modulate molecules of the ECM (extracellular matrix) which are known to modulate invasion. However, this complex mechanism is not detailed yet. Goal of this project is to define the role of TGF-ß2 in the invasion of high-grade glioma cells into healthy parenchyma. Methods: A set of published or possibly relevant factors of the ECM like Tenascin-C, Fibronectin, Vitronektin, Collagens, Versican, Laminin, Nestin and Vimentin were evaluate…

Schlagworte

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