CareLit Fachartikel

Bacteroides fragilis toxin (BFT) impairs epithelial barrier function of human colon in vitro

AC Schulz, AJ Kroesen, S Dullat, M Fromm, HJ Buhr · Zeitschrift für Gastroenterologie · 2006 · Heft 04

Dokument
1102523
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
AC Schulz, AJ Kroesen, S Dullat, M Fromm, HJ Buhr
Ausgabe
Heft 04 / 2006
Seiten
–
Erschienen: 2006-04-10 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2005-919837

Zusammenfassung

Introduction: Enterotoxigenic strains of Bacteroides fragilis produce a 20-kDa metalloprotease toxin (BFT) which is known to be associated with diarrheal disease in man. Anaerobic strains of Bacteroides fragilis are normal commensales of the intestinal flora. There is experimental evidence that the BFT alters the barrier function of the epithelial lining by degrading tight junction proteins like occludin, claudins, JAM, and ZO–1. Destruction of the epithelial barrier is paralleled by bacterial translocation, inflammation, and infection. Method: The effect of BFT (culture supernatant, sterile filtration, measurem…

Schlagworte

Bacteroides fragilis Bacteroides After Claudin-1 Claudin-2 Claudins Bacterial Translocation Bakterientoxine Claudin-4 Diarrhea Zeitschrift für Gastroenterologie