Differential activation of interferon responsive signalling pathways by type I and II interferons in parenchymal and non-parenchymal liver cells

The family of homologous type I interferons (IFN –α and –β) were originally identified for their potent antiviral activity but have also been shown to possess both antiproliferative and immunoregulatory properties. Both type I and type II interferons (IFN–γ) signal through distinct but related pathways, but still little is known about the specificity of interferon responses in different liver cells. We report here the differential activation of interferon responsive gene signalling pathways in murine parenchymal and non–parenchymal liver cells both on the transcriptional and translational level. To address this…