Expression of the multiligand receptor Megalin in hepatic stellate cells
S Hillebrandt, H Keppeler, R Weiskirchen, M Roderfeld, H Wasmuth, L Leifeld, E Roeb, AM Gressner, T Sauerbruch, F Lammert · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background: The LDL receptor-related protein–2 (Megalin) is the largest membrane receptor found in mammals and mediates the endocytic uptake of vitamin/protein binding complexes. Megalin is known to be expressed in the proximal tubules of the kidney and to play an important role during the embryonic development of the brain. The aim of this study was to investigate the expression of Megalin in liver and to assess its pathobiological function in vivo and in vitro. Methods: During CCl4-induced liver fibrosis in mice and after bile duct ligation in rats, hepatic Megalin expression was studied by RT-PCR and immunohi…
