CareLit Fachartikel

Chemoinducible Virotherapy for advanced ovarian cancer

I Herrmann, M Porten, A Menzel, DT Curiel, D Niederacher, P Dall · Zentralblatt für Gynäkologie · 2005 · Heft 10

Dokument
1102598
CareLit-ID
Jahr
2005
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zentralblatt für Gynäkologie
Autor:innen
I Herrmann, M Porten, A Menzel, DT Curiel, D Niederacher, P Dall
Ausgabe
Heft 10 / 2005
Seiten
–
Erschienen: 2005-10-18 00:00:00
ISSN
0044-4197
DOI
10.1055/s-2005-921017

Zusammenfassung

Objective of Study: Resistance of antineoplastic agents remains a barrier to the establishment of curative chemotherapy regimens for advanced ovarian cancer. Overexpression of the p-glycoprotein encoded by the MDR1 gene is known to mediate resistance to antineoplatstic drugs. We describe a chemoinducible virotherapy for chemoresistant OvCa using the MDR1 promoter controlling replication of conditionally replicating Adenovirus (CRAds). Methods: The inducibility of MDR1 by Doxorubicin (DOX) was analysed by RT-PCR and by luciferase reporter assays. Two CRAds were generated: Ad5/3mdrE1 was constructed by replacing t…

Schlagworte

Zentralblatt für Gynäkologie