Downregulation of cyclin B1 inhibits proliferation of breast cancer cells
J Yuan, I Androic, A Kraemer, M Kaufmann, K Strebhardt · Zentralblatt für Gynäkologie · 2005 · Heft 10
Bibliografische Angaben
Zusammenfassung
Introduction: Breast cancer is the most common malignancy among females worldwide and its incidence is increasing every year. Although improvements have been made in context of early diagnosis, surgical techniques, adjuvant hormone therapy, chemotherapy and radiotherapy, breast cancer is still a leading cause of cancer mortality. Growing knowledge of biological signalling pathways in breast cancer generates an increasing impact on clinical diagnosis and therapy. In spite of the well-established breast cancer genes, such as BRCA1, BRCA2, HER2 and p53, emerging studies indicate that uncontrolled high expression of…