CareLit Fachartikel
The role of plasmacytoid dendritic cells in IgE-mediated skin diseases
W Peng, Y Chunfeng, JP Allam, B Schlütter-Böhmer, AJ Hart, N Novak · Pneumologie · 2006 · Heft 01
Dokument
1102721
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Zusammenfassung
The high affinity receptor for IgE (FcεRI) on myeloid dendritic cells has been shown to play a major role in IgE-mediated skin diseases such as atopic dermatitis (AD). Plasmacytoid dendritic cells (pDC) which are instrumental in the defense of viral infections are present in reduced amounts in the skin of AD patients, which are characterized by a high susceptibility to viral infections. We explored phenotypical and functional characteristics of pDC in the peripheral blood of patients with AD and healthy individuals. BDCA2+CD123+ pDC have been enriched from the peripheral blood of patients with AD and studied in…
Schlagworte
Dendritic Cells
Blood
Dermatitis
Apoptosis
Cytokines
After
Pneumologie
