CareLit Fachartikel
PLGA-Nanospheres: Delivery tools for the treatment of liver fibrosis
S Benner, RM Pereira Paz, N Martini, R Weiskirchen, D Klee, AM Gressner · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Dokument
1102851
CareLit-ID
Jahr
2006
Publikation
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: Liver fibrosis and cirrhosis are a common consequence of the majority of chronic liver insults and represent a common and difficult clinical challenge of worldwide importance. Significant morbidity and mortality are associated with the development of liver fibrosis, and particularly cirrhosis. Thus, there is a considerable imperative to develop antifibrotic strategies that are applicable to liver fibrosis [1]. Biodegradable Poly(D,L-lactic-co-glycolic acid) (PLGA)-nanospheres were demonstrated to be a potent deliverer for peptides, proteins or DNA. They protect the embedded devices from enzymatic degradati…
Schlagworte
HSC
Hepatocytes
Kupffercells
PLGA-Nanospheres
liver fibrosis
sinusoidal endothelial cells
After
Zeitschrift für Gastroenterologie
