CareLit Fachartikel
Scavenger Receptor Class B Type I is a Hepatitis C Virus Receptor on Human Dendritic Cells
H Barth, EK Schnober, C Neumann-Haefelin, R Thimme, HE Blum, TF Baumert · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Dokument
1102862
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
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Zusammenfassung
Background and Aim: Interaction of dendritic cells (DCs) with viral particles may play an important role in the immunopathogenesis of HCV infection. Since the large-scale synthesis of infectious virions is limited, we have used insect-cell derived HCV-like particles (HCV-LPs) to study the interaction of HCV with DCs. Human monocyte-derived DCs efficiently internalize and cross-present HCV-LPs to HCV-specific CD8+ T cells demonstrating that HCV-LP-DC interaction represents an excellent model system to define the molecular mechanisms of HCV uptake and antigen presentation (Barth et al. 2005, Blood 105: 3605–14). M…
Schlagworte
Hepatitis C virus
cross-presentation
scavenger receptor
Antibodies
Dendritic Cells
Antigen Presentation
Blood
Hepatitis
Zeitschrift für Gastroenterologie
