Cellular Binding and Entry of Hepatitis C Virus Pseudotypes and Virus-like Particles Requires a Different Set of Cellular Co-receptors
A Haberstroh, H Barth, EK Schnober, JM Pestka, HM Diepolder, JT Gerlach, GR Pape, AH Patel, HE Blum, FL Cosset, TF Baumert · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and Aim: Due to the limitations of tissue culture systems for the study of hepatitis C virus (HCV) infection, surrogate model systems for the study of virus attachment and entry have been developed. Insect cell-derived HCV-like particles (HCV-LPs) have been used to study viral binding and uptake in hepatocytes and dendritic cells. Retroviral HCV pseudoparticles (HCVpp) allow the convenient study of HCV entry and neutralization. Using these model systems CD81, scavenger receptor class B type I (SR-BI) and heparan sulfate (HS) have been identified as (co-) receptors mediating virus attachment and entry.…
