Treatment of Severe Refractory Pruritus with Fractionated Plasma Separation and Adsorption (Prometheus®)
K Rifai, C Hafer, C Athmann, H Haller, D Fliser, MP Manns · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Severe pruritus is a serious complication of cholestatic liver disease. Prometheus® is a new extracorporeal liver support system combining high-flux hemodialysis and direct toxin adsorption of the patient`s albumin fraction (FPSA; fractionated plasma separation and adsorption). We prospectively evaluated the effect of Prometheus® therapy on patients with intractable pruritus. Methods: Seven patients with severe pruritus refractory to all medical treatment efforts over >4 weeks were treated with Prometheus® (3–5 times, 18±3 hours total). Mean age was 48±17 years, 5/7 patients were male. Underlying l…