Genetic characteristics of innate and adaptive immunity in coeliac disease
A Dezsőfi, B Szebeni, D Krikovszky, G Veres, A Körner, A Kapitány, I Korponay-Szabó, A Arató · Zeitschrift für Gastroenterologie · 2006 · Heft 06
Bibliografische Angaben
Zusammenfassung
Background/Aim: Beside the central role of the adaptive immune system disturbances of innate immunity is also responsible for the pathogenesis of celiac disease (CD), in which the activation of CD14 and TLR4 receptors may be key factors. As CD and type 1 diabetes mellitus (T1DM) can coexist frequently our aim was to study the frequency of CD14 (C-260T) and TLR4 (A+896G) single nucleotide polymorphisms (SNPs) in children with CD, T1DM and with the coexistence of CD and T1DM. The distribution of HLA-DQ alleles in the same groups was also studied. Methods: In 100 children with CD, in 87 with T1DM and in 62 with the…
