Inhibition of the synthesis of prostaglandins or nitric oxide at supraspinal or spinal level induces different actions on experimental gastric mucosal damage

The role of central nervous system in maintaining gastric mucosal integrity has been intensively studied in the last decade. Our previous findings suggest that activation of central (supraspinal) α2 adrenergic and opioid receptors result in gastric mucosal protection, since different opioid peptides and α2 adrenoceptor agonists given intracerebroventricularly (icv.) resulted in gastric mucosal protection against different types of gastric mucosal damage. Central nitric oxide is likely to be involved in mediation of gastroprotective effect, since inhibition of NO synthase by ice administration of NG-nitro-L-argin…