Neuroimmunomodulation in the iodoacetamine-induced gastritis in rats

Background and study aims: Defense mechanisms – including immune responses – of the gastrointestinal tract are influenced by the nervous system, however no reports are available about the changes of the distribution and density of neuropeptide containing nerve fibres and their contacts with the immunocompetent cells in experimental gastritis. Therefore our aim was to investigate the precise localization and density of the nerve fibers and immunocompetent cells and their contacts in iodoacetamine-induced gastritis in rats. Materials and Methods: substance P (SP), vasoactive intestinal polypeptide (VIP), neuropept…