Beneficial effect of zerumbone on cholecystokinin-octapeptide-induced acute pancreatitis in rats
A Szabolcs, L Tiszlavicz, J Kaszaki, C Varga, A Pósa, A Berkó, J Lonovics, T Takács · Zeitschrift für Gastroenterologie · 2006 · Heft 06
Bibliografische Angaben
Zusammenfassung
Aim: Our experiment was designed to investigate the effect of zerumbone pre-treatment on cholecystokinin-octapeptide-induced acute pancreatitis in rats. Methods: Male Wistar rats weighing 220–270g were used in this study. Animals were divided into 4 groups. Group ZP was treated with 20mg/kg zerumbone dissolved in 250µl DMSO ip. followed by three sc. injections of 100µg/kg cholecystokinin-octapeptide (CCK-8) with 1 hour differences. Group P received an ip. injection of DMSO followed by pancreatitis induction. Group Z received 20mg/kg zerumbone followed by injections of physiological saline. Group C was treated wi…