Near Normalization of Adhesion Molecule Plasma Concentrations after a 4-Weeks Physical Training Program in Patients with Abnormal Glucose Tolerance

Aims: The beneficial effects of physical activity on a reduced risk of coronary heart disease could at least in part be mediated by improved markers of endothelial dysfunction. The aim of this study was to determine the effect of 4 weeks of physical training on plasma concentrations of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in individuals with normal (NGT) or impaired (IGT) glucose tolerance, or type 2 diabetes (T2D). Methods: In 60 subjects with NGT (n=20) or IGT (n=20) glucose tolerance, or T2D patients (n=20) we measured the plasma concentrations of ICAM-1, VCAM-1, and E-selectin using commerci…