Reduction of postprandial blood glucose excursions by an optimised formulation of oral insulin
C Kapitza, L Nosek, E Arbit, P Beckett, R Gelfand, KM Porter, M Goldberg, T Heise · Diabetologie und Stoffwechsel · 2006 · Heft 06
Bibliografische Angaben
Zusammenfassung
Background and Aims: Oral Insulin (OI) formulated with Emisphere's Eligen technology has been shown to exhibit a blood glucose lowering effect with a rapid onset of action. This makes OI attractive for prandial insulin therapy, however, the effect of OI is blunted when administered together with food. The aim of this pilot study was to identify an insulin/carrier-ratio optimised for pre-prandial administration of OI. Methods: In a first subset of experiments, eight subjects with diet-treated Type 2 diabetes (age 56±6 years (mean±SD), BMI 29±4kg/m2, HbA1c 6.7±0.7%) received single-dose administrations of two diff…
