Identification of the chemokine CXCL9 (MIG) as a genetic modifier of liver fibrosis in patients with hepatitis C
HE Wasmuth, T Wiederholt, E Dahl, C Hellerbrand, J Halangk, T Berg, S Hillebrandt, D Scholten, R Weiskirchen, C Trautwein, F Lammert · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: Liver fibrosis in chronic hepatitis C (HCV) infection is influenced by multiple genetic and exogenous factors. Employing quantitative trait locus (QTL) analysis, we have recently identified the distal haplotype of mouse chromosome 5 as a genetic modifier of liver fibrosis. The present study was designed to validate this genetic association in patients with HCV infection and to investigate the expression of CXCL9 at different stages of fibrosis and in isolated human myofibroblasts of different donors. Methods: A human haplotype study was performed with 8 validated SNPs (HapMap) that cover the distal CXC che…
