CareLit Fachartikel
Epithelial-mesenchymal transdifferentiation of bile duct cells during fibrogenesis due to cholestasis
F Schulze, O Ostrowski, K Schardt, O Dirsch, U Töx, HP Dienes, M Odenthal · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Dokument
1103414
CareLit-ID
Jahr
2006
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Zusammenfassung
Epithelial-mesenchymal transition (EMT) was previously shown in kidney during tubulo-interstitial fibrosis. It is a process in which epithelial cell layers lose polarity plus cell-cell contacts and undergo cytoskeleton reorganization. In order to study whether bile-duct epithelial cells are able to undergo EMT during fibrogenesis we analysed liver tissues with cholestasis. Methods: Cryo-conserved and formalin-fixed, paraffin embedded liver tissue of sham operated and bile-duct ligated rats was investigated by immunohistochemistry. Antibodies against epithelial and mesenchymal marker proteins were used for immunh…
Schlagworte
Antibodies
Cholestasis
Beta-Catenin
beta Catenin
Desmin
Actin
Zeitschrift für Gastroenterologie
