Impact of exogenous VEGF administration after subtotal liver resection
M Bockhorn, S Schöllmann, B Opitz, SY Sheu, A Frilling, CE Broelsch, JF Schlaak · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: Recent data suggest that vascular endothelial growth factor (VEGF) can improve liver regeneration after partial hepatectomy. It is unclear, whether exogenous administration of VEGF can also be used to ameliorate impaired liver regeneration and improve overall survival after massive (90%) resection of the liver. Methods: To determine the effect of exogenous and endogenous VEGF after partial hepatectomy (PH), rats were subjected to 90% PH and treated with either VEGF, anti-VEGF or NaCl. Postoperatively (3h –4weeks) liver body weight ratio (LBR), hepatocyte proliferation (Ki-67) and biochemical markers (AST,…
