Telomerase limits chromosomal instability and promotes tumor progression at the ‘crisis’ stage of in vivo carcinogenesis
A Lechel, H Holstege, Y Begus, A Schienke, A Roy Choudhoury, K Kamino, U Lehmann, H Geerlings, R Geffers, J Buer, MP Manns, S Kubicka, P Schirmacher, J Jonkers, KL Rudolph · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: During early cancer formation most human epithelial cancers transit through a ‘crisis’ stage characterized by profound chromosomal instability associated with telomere dysfunction and loss of p53 checkpoint function. Methods: To analyze the role of telomerase reactivation during carcinogenesis at the crisis stage in vivo we generated a mouse model in which hepatocellular cancer (HCC) was induced by chronic liver damage (HBs), telomere dysfunction, targeted p53 deletion, and chromosomal instability thus closely resembling several molecular hallmarks of ‘crisis’ and human HCC. Results: The formation…
