Placental mesenchymal stem cells: A novel autologous stem cell graft for peripartum neural regeneration?
CB Portmann-Lanz, S Mohr, A Schoeberlein, A Huber, R Sager, A Malek, W Holzgreve, DV Surbek · Geburtshilfe und Frauenheilkunde · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Objective: To assess whether mesenchymal stem cells (MSCs) are present in placental tissue and if they have the potential to be differentiated into mesodermal and neuronal lineage, particularly in regard with possible neuroregeneration in brain injury in the premature infant. Design: MSCs were isolated from first and third trimester chorion, amnion and placental villous stroma. Mesenchymal (CD166, CD105, CD90, CD73, CD49e, CD44, CD29, CD13) and hematopoietic (CD14, CD34, CD45) stem cell markers as well as immunologic markers (MHC I&II) were used for analysis. After differentiation towards the mesodermal and neur…
