Wnt-Signaling genes and their potential as tumor markers for epithelial ovarian cancer
VA Heinzelmann-Schwarz, JP Scurry, RL Sutherland, NF Hacker, DA Fink, PM O'Brien · Geburtshilfe und Frauenheilkunde · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: The Wnt/beta-catenin-signaling pathway has been increasingly implicated in a variety of cancers, including epithelial ovarian cancer (EOC). However, the nature of Wnt-signaling defects other than beta-catenin are unknown. The frizzled protein sFRP4 has putative inhibitory activity of the Wnt-signaling cascade through binding and sequestering Wnt ligands. Fibroblast growth factors (FGF) have been described to interact with beta-catenin, TGF-beta and steroid receptors. FGF9 has recently been proposed to be a key downstream target contributing to the cancer phenotype of endometrioid EOC carrying Wnt-p…
