Urinary-type plasminogen activator and its receptor is elevated in G93A Mice

Introduction: The plasminogen system is involved in proteolysis in brain injury and inflammation and may also contribute to the pathogenesis of neurodegenerative diseases as has recently been shown in Alzheimers disease and Creutzfeldt-Jacob disease. As yet, there has been little investigation of the role of the plasminogen activator system in amyotrophic lateral sclerosis (ALS). Methods: We used zymography and PCR to analyze the expression of Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in spinal cord tissue from G93A mice. Results: PCR analysis of spinal cord of G93A mice showed, that expre…