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Fractionated stereotactic radiosurgery in rat brain: histopathological determination of dose-response and tolerance

A. Ernst-Stecken, I. Jeske, A. Hess, F. Rödel, G.G. Grabenbauer, R. Sauer, I. Blümcke · Aktuelle Neurologie · 2006 · Heft 09

Dokument
1103611
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Jahr
2006
Publikation
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
A. Ernst-Stecken, I. Jeske, A. Hess, F. Rödel, G.G. Grabenbauer, R. Sauer, I. Blümcke
Ausgabe
Heft 09 / 2006
Seiten
–
Erschienen: 2006-09-27 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2006-953467

Zusammenfassung

Fractionated stereotactic radiosurgery (fSRS) allows single or multiple high dosage radiation of small volumes within the brain, i.e. addressing intracranial tumors. Reasonable protection of perilesional brain parenchyma raises clinical interest in fSRS strategies and promising results were already achieved for numerous focal lesions (e.g.: arteriovenous malformations, brain metastases, small benign tumors and malignancies). The effect of hyperfractionated stereotactic radiosurgery on healthy brain tissue (e.g.: apoptosis, necrosis, impact on the blood-brain-barrier) remains, however, to be determined. Adult mal…

Schlagworte

After Arteriovenous Malformations Blood-Brain Barrier Apoptosis Blood Tumor Aktuelle Neurologie