Adiponectin receptor R1 gene expression is upregulated by valproic acid but not by topiramate in human hepatoma cell line, HepG2
M. Rauchenzauner, M. Laimer, G. Luef, S. Kaser, J. Engl, T. Tatarczyk, C. Ciardi, A. Tschoner, E. Haberlandt, M. Lechleitner, J. Patsch, C. Ebenbichler · Aktuelle Neurologie · 2006 · Heft 09
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Zusammenfassung
Purpose: To elucidate the effects of VPA compared to TPM on adipoR1 and adipoR2 mRNA expression in human hepatoma cell line HepG2. Methods: HepG2 cells were grown to confluence, all treatments were carried out after serum starvation. HepG2 cells were either unstimulated or exposed to VPA for 6 and 12 hours (h) at concentrations of 0.1 mM, 0.5 mM, 1 mM, and 5 mM or to TPM for 12, 24, and 48 hours at concentrations of 4 mM and 40 mM, respectively. In addition, TPM stimulation was performed in a concentration of 400 mM for 12 hours. Control cells were exposed to serum-free media only. mRNA of adipoR1 and adipoR2 we…
