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The PPARgamma agonist troglitazone inhibits proliferation and migration of malignant gliomas by targeting the TGFß pathway

R. Coras, A. Hölsken, J. Hauke, M. Reichel, C. Tränkle, R. Buslei, I. Blümcke, E. Hahnen · Aktuelle Neurologie · 2006 · Heft 09

Dokument
1103614
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Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
R. Coras, A. Hölsken, J. Hauke, M. Reichel, C. Tränkle, R. Buslei, I. Blümcke, E. Hahnen
Ausgabe
Heft 09 / 2006
Seiten
–
Erschienen: 2006-09-27 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2006-953497

Zusammenfassung

Rapid proliferation and diffuse brain infiltration are histopathological hallmarks of malignant gliomas and compatible with an constitutive activation of the transforming growth factor (TGF) ß – signaling pathway. Here, we identify the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist Troglitazone (TRO) as potent down-regulator of TGFß receptors in glioma cell lines obtained from rat, mouse or human species. Although the PPARgamma receptor is not detectable in rat F98 glioma cells, treatment with TRO significantly reduced cell proliferation (IC90=65µM) and was mediated by G0/1 cell cycle arres…

Schlagworte

Glioma Cells Ppargamma Proliferation Migration Malignant Gliomas Diffuse Brain Receptor Mediated Confirmed Aktuelle Neurologie