Comparison of tumour vascularisation by small animal ultrasound in a subcutaneous and an orthotopic xenotransplantation model in mice
C Heneweer, D Becker, D Emme, C Graeff, M Both, CC Glueer, H Kalthoff, M Heller · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2008 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: Subcutaneous xenotransplantation tumour models in mice are widely used although considerable differences in morphology, and metastatic capability have been reported in comparison to orthotopically implanted tumours. In this study, we compared vascularisation in subcutaneous vs. orthotopic tumours by small animal ultrasound. Material and Methods: 1×106 cells of the human pancreatic cancer cell line PancTu I were injected in 10 nude mice subcutaneously or orthotopically, respectively. We used a Vevo 770 small animal ultrasound device equipped with a 710B scanhead (Visualsonics, Toronto), and investig…
