Long-term dynamics of brain atrophy development in Multiple Sclerosis – a 10 year follow-up MRI study

Introduction: Brain atrophy is a known feature in multiple sclerosis (MS). Current studies suggest that atrophy may reflect the neurodegenerative and destructive components of the disease. There are indications that atrophy correlates with neurological impairment and disability, yet there is little data about its long term development. We investigated the course of brain atrophy over 10 years in 3 active MS patients who underwent MRI regularly. Methods: We analysed clinical and MRI data over a period from 1996 to 2008 of 3 patients with MS (mean observation period 10.3 years/per subject). Patients were examined…