CareLit Fachartikel

Cardiac denervation occurs independent of orthostatic hypotension and impaired heart rate variability in Parkinson's disease

C.A Haensch, H Lerch, J Jörg, S Isenmann · Aktuelle Neurologie · 2008 · Heft 09

Dokument
1103757
CareLit-ID
Jahr
2008
Publikation
PDF
nein
Metadaten
DOI
ja
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
C.A Haensch, H Lerch, J Jörg, S Isenmann
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-02 00:00:00
ISSN
0302-4350
DOI
10.1055/s-0028-1086777

Zusammenfassung

Patients with idiopathic Parkinson's Disease (PD) have impaired sympathetically mediated neurocirculatory innervation. Here we analyzed the correlation between cardiac 123I-metaiodobenzylguanidine (MIBG) uptake, orthostatic hypotension and heart rate variability in patients with PD. Orthostatic hypotension (OH) as a hallmark of sympathetic neurocirculatory failure was found with a high prevalence in PD. PD is known to affect the cardiac innervation, resulting in a suppressed heart rate variability and a postganglionic noradrenergic lesion. We measured continuous arterial blood pressure in rest and 70 head-up til…

Schlagworte

Blood Pressure Blood Respiration Baroreflex Affect Denervation Aktuelle Neurologie