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Combination of hyperbaric oxygenation and selective JNK-inhibition by D-JNK-I-1 as a potent neuroprotective strategy in a focal ischaemia/reperfusion injury model in rats

T Herdegen, J Liu, Y Zhao, G Deuschl, C.C Eschenfelder · Aktuelle Neurologie · 2008 · Heft 09

Dokument
1103772
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
T Herdegen, J Liu, Y Zhao, G Deuschl, C.C Eschenfelder
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-02 00:00:00
ISSN
0302-4350
DOI
10.1055/s-0028-1086927

Zusammenfassung

Background: In pervious studies, hyperbaric oxygenation (HBO) was proven as a potent neuroprotective treatment in animal models of acute stroke by reducing apoptotic cell death. Furthermore, c-Jun N-terminal kinase (JNK) is activated in ischaemic neurons downstream of the activated glutamate receptors and thus mediating neuronal cell death. The highly specific peptide JNK-inhibitor D-JNK-I-1 (XG-102) has been shown to be neuroprotective in acute stroke in mammals, acting by intracellular inhibition of JNK-kinase. We thus hypothesized that combination of both treatments might enhance the neuroprotective effect of…

Schlagworte

Treatment D-Jnk-I-1 Xg-102 Neuroprotective Following Acute Stroke Groups Combination Studies Death Activated Aktuelle Neurologie