Voxel-based morphometry at the single subject level: a pilot study in early Huntington's disease
M Mühlau, A Wohlschläger, C Gaser, M Valet, S Nunnemann, A Weindl, A Peinemann, T Etgen, R Ilg · Aktuelle Neurologie · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Voxel-based morphometry (VBM) has proved a powerful method to detect subtle changes of grey matter (GM) at the group level but the detection of GM changes in single subjects has not been investigated systematically. We tested two parametric approaches based on either the one-sample or two-sample t-test with a „pooled“ estimate of variance. Moreover, we tested two corrections for multiple statistical tests, namely, the family wise error correction predicated on Gaussian random fields (FWE) and the false discovery rate predicated on the procedure of Benjamini & Hochberg (FDR). We tested 22 patients in early stages…
