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Inhibition of tumor growth of MDA-MB–231 human breast cancers by targeted cytotoxic analogue of somatostatin AN–162 (AEZS–124)

S Seitz, AV Schally, A Treszl, A Papadia, O Ortmann, S Buchholz · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09

Dokument
1103816
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Jahr
2008
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
S Seitz, AV Schally, A Treszl, A Papadia, O Ortmann, S Buchholz
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-12 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0028-1088677

Zusammenfassung

It has been shown that human breast cancers express receptors for LHRH and somatostatin. In our previous studies we demonstrated that the growth of human breast cancer cell lines xenografted into nude mice can be inhibited by targeted cytotoxic analogues of LHRH (AN–152 (AEZS–108) and AN–207) as well as by targeted cytotoxic analogue of somatostatin AN–238. Consequently we decided to test targeted cytotoxic analogue of somatostatin AN–162 (AEZS–124) consisting of Doxorubicin (DOX) conjugated to somatostatin octapeptide RC–121. Experimental design: The expression of mRNA for somatostatin receptors in MDA-MB–231 h…

Schlagworte

AN-162 breast cancer somatostatin somatostatin receptor Breast Tumor After Geburtshilfe und Frauenheilkunde